It has been found to be effective for certain tumors of the prostate, head, neck, and brain, among others. When AFP HL analysis was applied to the validation cohort, the association between prolonged AFP HL and survival endpoints (hazard ratio, 11.63 and 16.39 P < 0.001) was confirmed.Brachytherapy is a method of treating cancer using a sealed radioactive source called a "seed" implanted directly inside the patient's body. A log-rank test followed by multivariate Cox analysis identified an independent function of prolonged AFP HL in predicting shorter recurrence-free survival and overall survival time after HCC resection (hazard ratios, 2.81 and 3.58 P < 0.001). Early recurrence within 2 years of resection was observed in 59% of the patients with prolonged AFP HL compared with only 29.3% of those with normal AFP HL ( P < 0.001). Long AFP HL was significantly associated with early postoperative recurrence ( P < 0.001), as was microvascular invasion. In the exploration cohort, 48 patients (21.3%) achieved early AFP complete resolution, 116 (51.6%) had normal HL, and 61 (27.1%) had prolonged HL. Overall, probabilities of recurrence and survival were estimated and compared across the AFP HL categories. We defined 3 categories of AFP HL: early complete resolution of AFP, normal HL, and prolonged HL if the HL exceeded 7 days. The analysis was based on cohorts of 225 (exploration set) and 117 (validation set) treatment-naïve HCC patients undergoing curative liver resection. There is still a paucity of early surrogate indicators of clinical endpoints after liver resection of hepatocellular carcinoma (HCC). To explore the prognostic value of the postsurgical half-life (HL) of serum alpha-fetoprotein (AFP).
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